Krebs

Liebe Leserinnen und Leser.

Krebs zählt bei Patienten, Angehörigen und Ärzten zu den beunruhigendsten Diagnosen überhaupt. Es handelt sich dabei um bösartige Veränderungen und das unkontrollierte Wachstum von Zellen im Körper. Krebs stellt auch für die moderne Medizin eine schwer zu bekämpfende Krankheit dar. Darüber hinaus belasten Chemo- und Radiotherapien den Organismus. Aus diesem Grund ist es sinnvoll diese Erkrankung mit allen Mitteln, auch auf natürlicher Basis, zu unterstützen.

Studien zu Kurkuma und Krebs

Eine Vielzahl von Studien setzt sich mit den möglichen Wirkungsweisen von Kurkuma und dessen Inhaltsstoff Curcumin bei der Krebserkrankung auseinander. Diese Studien listen wir Ihnen unten auf. Wir möchten aber um Ihre Nachsicht bitten, dass wir an dieser Stelle keinen wertenden Beitrag zu der Wirkungsweise bei Krebs erläutern.

  • Studien, die sich mit einer Infizierung von gesundem Gewebe auseinander setzen (1-6)
  • Studien, die sich mit der Zellteilung beschäftigen (7,8)
  • … als auch mit der Bildung wichtiger Proteine (9,19)
  • Studien, die sich mit der Hemmung der sog. Angiogenese beschäftigen (11-16)
  • Studien, welche die Hemmung von wichtigen Signalwegen untersuchen (17-20; ,36)
  • weitere Studien zu Kurkuma in Zusammenhang mit Krebs (21-35)

Bitte haben Sie Verständnis, dass wir aus juristischen, ethischen und moralischen Gründen dieses Thema nicht weiter durchleuchten und Ihnen gegenüber keine Wirkaussagen tätigen möchten. Dies wäre für uns nicht vertretbar.

 

 Studien zu Kurkuma und Krebs im Detail:

(1) Chen, B., Zhang, Y., Wang, Y., Rao, J., Jiang, X., & Xu, Z. (2014). Curcumin inhibits proliferation of breast cancer cells through Nrf2-mediated down-regulation of Fen1 expression. Journal of Steroid Biochemistry and Molecular Biology, 143, 11–18.

(2) Mohammad, P., Nosratollah, Z., Mohammad, R., Abbas, A., & Javad, R. (2010). The inhibitory effect of Curcuma longa extract on telomerase activity in A549 lung cancer cell line. African Journal of Biotechnology, 9(6), 912–919.

(3) Arezoomand, R., Zarghami, N., Rahmati, M., Pourhassan-Moghaddam, M., Nejati-Koshki, K., Delazar, a, … Maleki, M. J. (2010). The inhibitory effect of curcuma longa total extract on telomerase gene expression and activity in MCF-7 breast cancer cell line. Pharmaceutical Sciences, 16(3), 131–138.

(4) Yue, G. G. L., Chan, B. C. L., Hon, P. M., Lee, M. Y. H., Fung, K. P., Leung, P. C., & Lau, C. B. S. (2010). Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food and Chemical Toxicology, 48(8-9), 2011–2020.

(5) Gao, X.-F., Li, Q.-L., Li, H.-L., Zhang, H.-Y., Su, J.-Y., Wang, B., … Zhang, A.-Q. (2014). Extracts from Curcuma zedoaria Inhibit Proliferation of Human Breast Cancer Cell MDA-MB-231 In Vitro. Evidence-Based Complementary and Alternative Medicine: eCAM, 2014, 730678.

(6) Chen, X., Pei, L., Zhong, Z., Guo, J., Zhang, Q., & Wang, Y. (2011). Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine, 18(14), 1238–1243. H

(7) Lim, C.-B., Ky, N., Ng, H.-M., Hamza, M. S., & Zhao, Y. (2010). Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative Cancer Therapies, 9(1), 36–49.

(8) Liu, H., Liang, Y., Wang, L., Tian, L., Song, R., Han, T., … Liu, L. (2012). In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PloS One, 7(10), e48075.

(9) Chen, H.-W., Lee, J.-Y., Huang, J.-Y., Wang, C.-C., Chen, W.-J., Su, S.-F., … Yang, P.-C. (2008). Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Research, 68(18), 7428–7438.

(10) Shishodia, S., Singh, T., & Chaturvedi, M. M. (2007). Modulation of transcription factors by curcumin. Advances in Experimental Medicine and Biology, 595, 127–148

(11) Anand, K., Sarkar, A., Kumar, A., Ambasta, R. K., & Kumar, P. (2012). Combinatorial Antitumor Effect of Naringenin and Curcumin Elicit Angioinhibitory Activities In Vivo. Nutrition and Cancer, 64(5), 714–724.

(12)Binion, D. G., Otterson, M. F., & Rafiee, P. (2008). Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut, 57(11), 1509–1517. (13) Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009). Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. The Journal of Nutrition, 139(5), 919–925.

(14) El-Azab, M., Hishe, H., Moustafa, Y., & El-Awady, E. S. (2011). Anti-angiogenic effect of resveratrol or curcumin in Ehrlich ascites carcinoma-bearing mice. European Journal of Pharmacology, 652(1-3), 7–14.

(15) Liu, H., Liang, Y., Wang, L., Tian, L., Song, R., Han, T., … Liu, L. (2012). In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PloS One, 7(10), e48075.

(16) Perry, M.-C., Demeule, M., Régina, A., Moumdjian, R., & Béliveau, R. (2010). Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts. Molecular Nutrition & Food Research, 54, 1192–1201.

(17) Chen, X., Pei, L., Zhong, Z., Guo, J., Zhang, Q., & Wang, Y. (2011). Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine, 18(14), 1238–1243.

(18)Kizhakkayil, J., Thayyullathil, F., Chathoth, S., Hago, A., Patel, M., & Galadari, S. (2010). Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells. Biochemical and Biophysical Research Communications, 394(3), 476–81.

(19) Li, M., Zhang, Z., Hill, D. L., Wang, H., & Zhang, R. (2007). Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Research, 67(5), 1988–96.

(20) Yallapu, M. M., Jaggi, M., & Chauhan, S. C. (2012). Curcumin nanoformulations: A future nanomedicine for cancer. Drug Discovery Today, 17(1-2), 71–80.

(21) Aratanechemuge, Y., Komiya, T., Moteki, H., Katsuzaki, H., Imai, K., & Hibasami, H. (2002). Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Int J Mol Med, 9(5), 481–484. Retrieved from

(22) Chauhan, D. P. (2002). Chemotherapeutic potential of curcumin for colorectal cancer. Current Pharmaceutical Design, 8(19), 1695–706.

(23)Hilchie, A. L., Furlong, S. J., Sutton, K., Richardson, A., Robichaud, M. R. J., Giacomantonio, C. a, … Hoskin, D. W. (2010). Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria. Nutrition and Cancer, 62(3), 379–89.

(24)Jaruga, E., Salvioli, S., Dobrucki, J., Chrul, S., Bandorowicz-Pikuła, J., Sikora, E., … Bartosz, G. (1998). Apoptosis-like, reversible changes in plasma membrane asymmetry and permeability, and transient modifications in mitochondrial membrane potential induced by curcumin in rat thymocytes. FEBS Letters, 433(3), 287–93.

(25) Kuo, C.-L., Wu, S.-Y., Ip, S.-W., Wu, P.-P., Yu, C.-S., Yang, J.-S., … Chung, J.-G. (2011). Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. International Journal of Oncology, 39(2), 319–28.

(26) Lim, C.-B., Ky, N., Ng, H.-M., Hamza, M. S., & Zhao, Y. (2010). Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative Cancer Therapies, 9(1), 36–49.

(27) Liu, H., Liang, Y., Wang, L., Tian, L., Song, R., Han, T., … Liu, L. (2012). In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog. PloS One, 7(10), e48075.

(28) Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., … Hsieh, C. Y. (2001). Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Research, 21(4B), 2895–900.

(29) Garcea, G., Berry, D. P., Jones, D. J. L., Singh, R., Dennison, A. R., Farmer, P. B., … Gescher, A. J. (2005). Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiology Biomarkers and Prevention, 14(1), 120–125.

(30) Li, M., Zhang, Z., Hill, D. L., Wang, H., & Zhang, R. (2007). Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Research, 67(5), 1988–96.

(31) Mahady, G. B., Pendland, S. L., Yun, G., & Lu, Z. Z. (2002). Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Research, 22(6C), 4179–4181. Retrieved from

(32) Park, J. H., Park, K. K., Kim, M. J., Hwang, J. K., Park, S. K., & Chung, W. Y. (2008). Cancer chemoprotective effects of Curcuma xanthorrhiza. Phytotherapy Research: PTR, 22(5), 695–698.

(33) Yue, G. G. L., Chan, B. C. L., Hon, P. M., Lee, M. Y. H., Fung, K. P., Leung, P. C., & Lau, C. B. S. (2010). Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food and Chemical Toxicology, 48(8-9), 2011–2020.

(34) Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., & Brenner, D. E. (2008). Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects., 17(6), 1411–1417.

(35) Aggarwal, B. B., Kumar, A., & Bharti, A. C. (2003). Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Research, 398(1 A), 363–398.

(36) Jurenka, J. S., & Ascp, M. T. (2009). Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alternative Medicine Review: A Journal of Clinical Therapeutic, 14(2), 141–53.